Large doses of psychedelic drugs like LSD/DMT/Psilocybin are well-known to produce enduring changes in creativity, mood and cognition in users. More recently, it has been claimed that regular, small “microdoses” of psychedelics at sub-perceptual levels can produce similar effects. While some survey data supports this claim the limited laboratory-based research conducted so far has not supported the various claims of microdosers.

However, these laboratory-based studies lack real-world validity. In this talk, I will describe a microdosing study we are about to conduct with volunteers microdosing LSD at home, on prescription, and determine whether psychological changes occur that cannot be explained by placebo effects. The results will not only affect our understanding of how psychedelic drugs work but impact the growing societal practice of LSD microdosing.

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